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En personas con diabetes tipo 2, el efecto incretina global est significativamente disminuido, aproximadamente un 50-70%

When Standard GLP-1 Dosing Isn't Enough: A Provider Decision Framework If you've been on a stable GLP-1 dose for 8-12 weeks without meaningful weight loss, several clinical decisions emerge: dose escalation, medication switching, combination therapy, or investigating underlying barriers like poor adherence, diet quality, or unaddressed metabolic conditions

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